"Metabolome Analyses"

Strategies for Systems Biology

edited by Vaidyanathan, Seetharaman; Harrigan, George G.; Goodacre, Royston

Springer, 2005, 383 pages. $149.00 + shipping ($8.00, U.S. or $20.00 Elsewhere)

Metabolome analyses is now recognized as a crucial component of functional genomic and systems biology investigations. Innovative approaches to the study of metabolic regulation in microbial, plant and animal systems are increasingly facilitating the emergence of systems approaches in biology. This book highlights analytical and bioinformatics strategies now available for investigating metabolic networks in microbial, plant and animal systems. The contributing authors are world leaders in this field and they present an unambiguous case for pursuing metabolome analysis as a means to attain a systems level understanding of complex biological systems.

Contents

Towards integrative functional genomics using yeast.- Metabolomics for assessment of functional diversity and quality traits.- Metabolomics: new approach towards identifying biomarkers and therapeutic targets.- Comparative metabolome profiling using two dimensional thin layer chromatography.- Capillary electrophoresis and application.-Metabolite profiling with GC-MS and C-MS.- Application of electrochemistry to metabolic profiling.- Differential metabolic profiling for biomarker discovery.- NMR-based metabonomics in toxicology research.- Methodological issues and experimental design considerations in metabolic profile-based class.- Modelling of fungal metabolism.- Detailed kinetic models using metabolomics data sets.- Metabolic networks.- Metabolic networks from sys. perspective.- Parallel metabolite and transcript profiling.- Fluxome profiling.- Targeted drug design and metabolic pathway flux.- Metabonomics in pharma. industry.- How lipidomic approaches will benefit pharma. industry.- Metabolites and fungal virulence.

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